Different types of mycoses especially invasive mycoses caused by yeasts and molds. are a growing problem in healthcare Candida albicans is one of the most common opportunistic fungi responsible for these kinds of infections the most notable explanation for this increase is a rise in the number of immunocompromised patients owing to advances in transplantation, the emergence of AIDS and rise m the number of invasive surgical procedures. Conveniently accessible hydrazide derivatives of benzoic acid 1 were converted to new thiosemicarbazides. Triazoles and alkylthiotriazoles. The antibacterial and antifungal activities were determined .Some of the newly synthesized compounds showed weak corresponding activities.