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169354

EVALUATION OF SOME ADDITIVES AS RELEASE RETARDANTS IN SUSTAINED RELEASE THEOPHYLLINE TABLETS

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Last updated: 22 Jan 2023

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Abstract

Sustained release matrix tablets involve mixing the active ingredient(s) with proper release retarding agent(s). In this study, theophylline anhydrous (THF) matrix tablets were prepared using different concentrations of magnesium stearate or ethylcellulose as release retarding materials. At certain concentrations, both substances were capable of retarding the drug release. However, high concentrations of magnesium stearate has led to poor physical properties such as low hardness and increased friability. On the contrary, increasing the concentration of ethylcellulose has improved both hardness and friability which may be regarded due to its binding properties. The optimum formulation was chosen on the basis of tablet mechanical properties and in vitro drug release. The selected tablet formulations had optimum hardness, low friability and acceptable dissolution pattern regarding to USP XXX dissolution regulations. Through applying kinetic equation models, the release mechanism of the drug from the selected formulations was found to follow Higuchi's kinetic model. This indicates that the drug release from the selected formulated tablets was mainly due to diffusion rather than matrix erosion.

DOI

10.21608/zjps.2009.169354

Authors

First Name

Hussein

Last Name

Sayed

MiddleName

-

Affiliation

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.

Email

hussein.sayed@yahoo.com

City

-

Orcid

-

First Name

Mamdouh

Last Name

Ghorab

MiddleName

-

Affiliation

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.

Email

mamdouh.ghorab@yahoo.com

City

-

Orcid

-

First Name

Hassan

Last Name

Ghonaim

MiddleName

-

Affiliation

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.

Email

hassan.ghonaim@yahoo.com

City

-

Orcid

-

First Name

Sheded

Last Name

Sheded

MiddleName

-

Affiliation

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.

Email

sheded.sheded@yahoo.com

City

-

Orcid

-

First Name

Khafagy

Last Name

Elsayed

MiddleName

-

Affiliation

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.

Email

khafagy.elsayed@yahoo.com

City

-

Orcid

-

First Name

Mariam

Last Name

Kamel

MiddleName

-

Affiliation

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.

Email

mariam.kamel@yahoo.com

City

-

Orcid

-

Volume

18

Article Issue

1

Related Issue

23548

Issue Date

2009-06-01

Receive Date

2009-02-04

Publish Date

2009-06-01

Page Start

23

Page End

29

Print ISSN

1110-5089

Online ISSN

2356-9786

Article File

ZJPS_Volume 18_Issue 1_Pages 23-29.pdf

PDF . 1.9MB

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https://zjps.journals.ekb.eg/article_169354.html

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https://zjps.journals.ekb.eg/service?article_code=169354

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Original Article

Type Code

862

Publication Type

Journal

Publication Title

Zagazig Journal of Pharmaceutical Sciences

Publication Link

https://zjps.journals.ekb.eg/

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Article

Created At

22 Jan 2023