161991

DEVELOPMENT AND EVALUATION OF FAST DISSOLVING TABLETS OF GLIMEPIRIDE

Article

Last updated: 04 Jan 2025

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Abstract

The objective of the current study was to assess the feasibility of developing fast dissolving tablets of glimepiride for type-2 diabetic patients, by direct compression and sublimation techniques. The formulations were prepared by direct compression method using super disintegrants like crospovidone, croscarmellose sodium and hydroxy propyl cellulose. Formulations by sublimation technique were prepared using camphor. The prepared tablets were evaluated for weight variation, hardness, friability, drug content, wetting time, thickness and disintegration time. Dissolution studies were carried out with USP type II dissolution apparatus using phosphate buffer (pH 6.8) at 37 ± 0.5°C. The properties of the tablets did not show any significant variations and were found to have good physical integrity except with disintegration time and wetting time. In vitro release studies indicate higher drug dissolution rate in two formulations and were subjected to stability studies. The stability data suggested that the prepared formulations were stable during the study period. Given the excellent data, it can be concluded that the fast dissolving tablets of glimepiride can be formulated by direct compression and sublimation techniques.

DOI

10.21608/zjps.2011.161991

Authors

First Name

BANDAR

Last Name

AL-DHUBIAB

MiddleName

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Affiliation

Department of Pharmaceutical Sciences, Faculty of Clinical Pharmacy, King Faisal University, Al-Ahsa, KSA

Email

bandar.al-dhubiab@yahoo.com

City

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Orcid

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Volume

20

Article Issue

2

Related Issue

23545

Issue Date

2011-12-01

Receive Date

2011-06-26

Publish Date

2011-12-01

Page Start

1

Page End

5

Print ISSN

1110-5089

Online ISSN

2356-9786

Link

https://zjps.journals.ekb.eg/article_161991.html

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https://zjps.journals.ekb.eg/service?article_code=161991

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1

Type

Original Article

Type Code

862

Publication Type

Journal

Publication Title

Zagazig Journal of Pharmaceutical Sciences

Publication Link

https://zjps.journals.ekb.eg/

MainTitle

DEVELOPMENT AND EVALUATION OF FAST DISSOLVING TABLETS OF GLIMEPIRIDE

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Article

Created At

22 Jan 2023