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163438

Spectrophotometric determination of ranitidine hydrochloride and famotidine using 1,2- naphthoquinone-4-sulphonate.

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Last updated: 22 Jan 2023

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Abstract

Accurate, simple and sensitive spectrophotometric method was developed for the determination of ranitidine hydrochloride and famotidine in bulk and pharmaceutical dosage forms. The method was based on the reaction of these drugs with 1,2-naphthoquinone-4sulphonate in alkaline medium, producing colored products measured atʎmax  488nm and 468 nm for ranitidine HCI and famotidine, respectively . Beer's law was obeyed in the concentration range from (24-120 µg ml -1) for ranitidine HCI and (6-20 µg ml -1) for famotidine with molar absorpitivity 1.498 x 103 Lmol-1 cm -1and 1.441 x 104Lmol-1 cm-1 respectively. The proposed method was successfully applied for the determination of ranitidine HCI and famotidine in their dosage forms with good accuracy and precisions.

DOI

10.21608/zjps.2013.163438

Authors

First Name

Mohamed

Last Name

Elsadek

MiddleName

-

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

Email

meelsadek@pharmacy.zu.edu.eg

City

-

Orcid

-

First Name

Mohamed

Last Name

Baraka

MiddleName

-

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

Email

mmbaraka@pharmacy.zu.edu.eg

City

-

Orcid

-

First Name

Lobna

Last Name

Abdel-Aziz

MiddleName

-

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazige University, Zagazig, Egypt

Email

lmabdel-aziz@pharmacy.zu.edu.eg

City

-

Orcid

-

First Name

Samar

Last Name

El-Bermawi

MiddleName

-

Affiliation

Department of Medicinal Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

Email

ssel-bermawi@pharmacy.zu.edu.eg

City

-

Orcid

-

Volume

22

Article Issue

2

Related Issue

21911

Issue Date

2013-12-01

Receive Date

2013-08-11

Publish Date

2013-12-01

Page Start

8

Page End

17

Print ISSN

1110-5089

Online ISSN

2356-9786

Article File

ZJPS_Volume 22_Issue 2_Pages 8-17.pdf

PDF . 2.3MB

Link

https://zjps.journals.ekb.eg/article_163438.html

Detail API

https://zjps.journals.ekb.eg/service?article_code=163438

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Type

Original Article

Type Code

862

Publication Type

Journal

Publication Title

Zagazig Journal of Pharmaceutical Sciences

Publication Link

https://zjps.journals.ekb.eg/

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Article

Created At

22 Jan 2023