Emergence of antimicrobial resistance among the most important bacterial pathogens is recognized as a major public health threat affecting humans worldwide. Infections caused by resistant bacteria lead to up to two-fold higher rates of adverse outcomes compared with similar infections caused by susceptible strains. The negative impacts of antibacterial resistance can be measured at the patient level by increased morbidity and mortality, at the healthcare level by increased resource utilization, higher costs and reduced hospital activity and at the society level by antibiotic treatment guidelines favoring increasingly broad-spectrum empiric therapy.
In this study 67 isolates were collected from patients admitted to ICUs of Zagazig University Hospitals, Sharqia, Egypt. The isolates were biochemically identified and their susceptibility to different antimicrobials were tested by Kirby-Bauer standard disk diffusion method.
The results showed that the recovered bacteria had high degree of resistance to different antimicrobial classes and 86.25 % were multi drug resistance (MDR). In conclusion high rate of MDR were found in this study that necessitate strict antibiotic dispensing policy to reduce the increased antibiotic resistance.