The objective of the study was to study the protective effect of Zizyphus spina christi extract (ZSC) on hepatic ischemia-reperfusion (I/R) injury in rats. Rats were randomly divided into four groups.Ischemia /reperfusion (I/R) groups, were received p.o saline, p.o(ZSC) (400 mg/ kg) 60 min before surgery and rats were I.P. injected with 30 mg/kg Bisphenol A diglycidyl ether (BADGE) 30 minutes prior to administration of(ZSC). I/R caused increase level of liver enzymes AST, ALT, ALP and LDH, also it increased level of proinflammatory mediators TNF-α, NO, and MDA. Whereas I/R caused significant decrease on IL-10, SOD, and GSH. The current study showed that ZSC extract protects liver against I/R since it increased antioxidants, reduced liver enzymes and inhibited the inflammatory mediators. On the other hand, injection of BADGE attenuates the effect of ZSC extract on the measured parameters. The study indicates that ZSC exerts antioxidant and anti-inflammatory effect in ischemic liver. This effect may be through the peroxisome proliferator-activated receptor-gamma (PPAR γ).