Malaria is still a major public health issue in several areas around the world. Due to Plasmodium falciparum's extensive resistance to practically all frontline treatments, massive attempts to combat malaria have been significantly hampered. The search for novel molecules in the sea organisms could lead to new therapies, including malaria. They are desperately needed to address the rise in resistance. Secondary metabolites produced by marine-derived species are structurally new and biologically potent, and they have become intriguing and valuable resources for drug discovery. Among more than 30,000 marine-derived compounds, numerous metabolites belonging to various chemical classes have shown potential efficacy against malaria. They include alkaloids, polyketides, steroids, terpenoids, peptides, and others. The current article presents concise and updated advances highlighting the potential candidates, particularly those isolated from marine sponges and cyanobacteria targeting the different stages of the malarial life cycle for disease management. Hence, this research can open novel resources of bioactive compounds for novel candidates for malaria management and other vector-borne diseases and exploring the oceans and seas treasures, where one-half of the global biodiversity exists.