Abstract: Objectives: This study compared the clinical and radiographic effects of two medicaments. Subjects and Methods: Endodontic treatment was performed on 26 pulpally involved primary molars in 4 to 7 years old children suffering from badly decayed or carious primary teeth which indicated for root canal treatment. Two medicaments (3Mix and ZOE) on the pulpectomized teeth comprised 2 main groups. The root canals were obturated with zinc oxide eugenol mix in the first group and a mixture of calcium hydroxide, zinc oxide, and 10% sodium fluoride solution in the second group , using hand-operated lentulo-spirals. The teeth were evaluated clinically and radiographically at different intervals (3 months,6 months, 12 months). Results: In the first group, pulpectomy with zinc oxide eugenol gave raise a 92.3% success rate, while the second group with triple antibiotic paste was 84.6%.Conclusion: Shows that ZnOE offers good clinical and radiographical results when compared with Tiple mix paste but with no statistically significant differences.