Objective: The objective of this study was to evaluate the effect of remineralizing agents on bond strength of resin composite to dentin with different adhesive systems after different storage times. Materials and methods: Twentyfour molars with flat occlusal dentin surfaces were prepared. These molars were randomly divided, according to the type of the remineralizing agents, into four main groups: nano hydroxyapatite (A), sodium fluoride (B), fluoro-hydroxyapatite (C) and control group (D); 6 specimens per group. Each group was subdivided into two equal subgroups, 3 molars each, according to the type of adhesive system, into Adper Easy One (subgroup E) and Adper Single Bond (subgroup T). Each subgroup was further subdivided into three divisions according to storage time into one day storage (S1), one month storage (S2) and three months storage (S3). Five specimens were obtained from each division, making a total of 120 specimens. Results: Different remineralizing agents and adhesive systems produced significant effect on mean micro shear bond strength (p =.027and p = .001 respectively). Also, storage time had a significant effect on micro shear bond strength (MPa) where (p =0.027). Conclusion: Remineralizing agents can be used successfully under resin composite restorative material. Storage time has a positive effect on the bond strength between dentin and resin composite.