Objectives: The aim of this study was to evaluate the apical leakage of zinc oxide eugenol-based endodontic sealer with and without the addition of amoxicillin. Materials and methods: Thirty, single-rooted, anterior teeth were flattened to create a standardized length of 14±1mm. The canals were prepared using crown-down technique with ProTaper Universal rotary system. The roots were divided into two experimental groups (n=10) according to the sealer used and two control groups (n=5).
Group 1: obturated using gutta percha and zinc oxide and eugenol-based sealer, Group 2: obturated using gutta percha and zinc oxide and eugenol-based sealer with amoxicillin antibiotic. Negative control group: (n=5).Positive control group: (n=5). Results: there was no statistically significant difference between sealer and sealer with antibiotic groups for apical leakage results. Conclusion: Adding amoxicillin to zinc oxide and eugenol-based sealer did not affect the sealing ability of the sealer.