Objective: The aim of the present study was directed to evaluate clinically and radiographically the effect of Ledermix material versus formocresol as a capping material for pulpotomized primary teeth. Materials and methods: This study was performed on 60 primary molars. Children of 4-8y age were selected from the pediatric dental outpatients' clinic, faculty of dental medicine, Al-Azhar University. The teeth were divided into 2 main groups. Each group formed of 30 primary molars. Group A: 30 primary molars were capped using formocresol. Group B: 30 primary molars were capped using Ledermix. The teeth were assessed clinically and radiographically at 3 different intervals (1-day post-operative, 1 month, and 3 months), using standard clinical and radiographic criteria. Results: It was found that Ledermix offered good clinical and radiographical results when compared with formocresol but with no statistically significant differences. Formocresol vital pulpotomy (group A) showed 86,7% success rate, while the Ledermix vital pulpotomy technique (group B) showed a higher success rate (90%). Conclusion: Ledermix vital pulpotomy has better prognosis compared to formocresol. However, the difference between them is not statistically significance.