Aim: This research was designed to evaluate the effect of dentin wetness and solvents containing of one step self-etch adhesives on the microtensile bond strength (mTBS) of dentin at different storage times. Materials and method: Occlusal dentin of 54 extracted human molars was exposed. Then, each adhesive agent was applied according to manufacturer instructions to wet and dry dentin surface, then composite resin was incrementally built up. Bond strengths to dentin were determined using mTBS test after water storage for 24 hours, one month, and six months. Results: solvent containing self-etch adhesives provided higher initial mTBS than solvent free self-etch adhesive system. Dentin dryness increased the mTBS with solvent containing adhesives, while decrease the mTBS with solvent free adhesive. No statistical significance difference was found between different storage times in mTBS for solvent free adhesive, while a statistical significance difference was found between different storage times in mTBS for solvent containing adhesives. Conclusion: Solvent free in self-etch adhesive has adverse effect on dentin bond strength in short term, but enhances the durability of dentin bond strength.