In regenerative endodontics, scaffold developed a frame work that supports growth and development of stem cells and vasculature inside the root canal. The suggested protocol for scaffold creation entails the intentional induction of bleeding from the periapex and the formation of an intracanal blood clot. Recently the autologous platelet concentrates were used to as intra canal scaffolds. In this study PRF was compared with blood clot as a scaffold in the process of pulp regenration.17 patient with 20 non-vital immature central incisors were included in this study. The teeth were scanned with CBCT, then the teeth were accessed and the infection was controlled using irrigation with 1.25% NaOCl and TAP application during the first visit. During the second visit the teeth were grouped into two groups according to the scaffold: PRF group (n=10) and BC group (n=10). The canals were sealed at the coronal part using MTA then the access cavity was filed using bonded composite resin. The teeth were followed up for 1 year in which they were scanned using CBCT at 6 and 12 months. After 12 months the root length, dentin wall thickness, periapical radiolucency, periapical bone density and the apical foramen were compared with preoperative measurement. The data was collected, tabulates and statistically analyzed. The results showed that there was no significant difference between the study groups except with young age in PRF group and this was similar to another published research.