The aim of this study is to evaluate the microbial effect of endo – solution and sodium hypochlorite on Entrococcus Feacalis on non- vital primary anterior teeth. Methodology: Forty teeth with early childhood caries were selected from Pedodontics Outpatients Clinic, Faculty of Dental Medicine, Boys, Cairo, Al- Azhar University, during  period  of  2014 - 2016.  The teeth were classified into two equal groups (A&B) each group formed of 20 teeth.  Group (A)  teeth were irrigated with endo-solution (EDTA 15%) after pulpectomy  procedure.  Group (B) teeth were irrigated with sodium hypochlorite 2.25% after pulpectomy procedure.  The sample taken before and after 48 hours post irrigation.  Results :  Sodium hypochlorite decreased the bacterial count from 5708.33 to 1650 (P = 0.002).  While EDTA decrease bacterial count from 13334.16 to 6471 ( P =0.252).      Conclution:  Both EDTA and sodium hypochlorite have positive  effect on Efeacalis but sodium hypochlorite more effective than EDTA.