The purpose of the study was to evaluate mineralized plasmatic matrix (MPM) as a graft material in reducing the complications associated with the surgical extraction of impacted mandibular third molar. Patients & Methods: The study was conducted on selected 26 patients. Their ages ranged from 19 to 38 years old with mean (SD) of 28.0 (6.67). The patients were selected and divided randomly into two groups (13 patients each). All the patients were subjected to surgical removal of impacted mandibular third molar by the same surgical team and using the same surgical protocol for both groups. After surgical extraction, the sockets in the first (study) group filled with mineralized Plasmatic matrix (MPM), while in the second (control) group, the socket closed without any graft. The patients were evaluated pre and post surgery at 1^st, 3^rd, 5^th, 7^th & 15 days to evaluate pain, trismus, facial swelling and thermal sensitivity of lower second molar. Bone density was evaluated immediately and at 1, 3 and 6 months postoperatively. The results showed; that the pain, trismus, and facial swelling in addition to thermal sensitivity were higher in the control group when compared with the MPM group, with statistically significant differences in some evaluation periods.  Bone density was higher in MPM group than in control group with high significant difference (P< 0.01). The conclusion: of this study showed that MPM application after surgical removal of impacted mandibular third molar was more effective as a graft material for reducing the surgical complications through the whole postoperative period.