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71571

The effect of simvastatin drug on osteogenesis around titanium implant (radiographic and histomorphometric analysis)

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Last updated: 22 Jan 2023

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Abstract

Understanding the feature of bone repair and osseointegration may aid in the development of therapeutics to improve implant outcomes. Statins are cholesterol-lowering drugs that have been reported to promote bone formation. The purpose of this investigation is to determine the effect of simvastatin drug on the enhancement of bone formation around titanium implants. Sixty male Sprague Dawely rats ranging in weight between 200-300 grams received pure titanium implants in the tibiae. The animals divided into A, B and C groups, A and B groups were intra-peritoneally administered 5 and 10 mg/ kg of simvastatin daily respectively. Animals of Group C were injected with isotonic saline. A, B and C groups were subdivided into 1, 2, 3 and 4 subgroups according to injection periods. After 4weeks, the animals were sacrificed, and specimens were prepared. Bone density in the medullary canal and percentage of cortical bone were obtained using cone-beam radiograph. Bone density of both groups A and B were significantly greater than those of the C group. Histomorphometric analysis to the specimens showed that statin increased bone formation in animals of group A and B more than those of group C. In conclusion, a simvastatin dose of 5 mg/ kg or higher increased medullary bone formation around the titanium implant.

DOI

10.21608/ajdsm.2018.71571

Authors

First Name

Mohamed

Last Name

A. Osman

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Affiliation

Professor, Department of Oral and Maxillofacial Surgery Faculty of Oral and Dental Medicine, Boys, Cairo Al-Azhar University

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First Name

Mohamed

Last Name

O. Abd El-Akher

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Affiliation

Professor, Department of Oral and Maxillofacial Surgery Dean of Faculty of Oral and Dental Medicine, Boys, Cairo Al-Azhar University

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Orcid

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First Name

Mohamed

Last Name

M. Antar

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Affiliation

Dentist, Alexandria Dental Research Center, Egyptian Ministry of Health

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Volume

21

Article Issue

3

Related Issue

10890

Issue Date

2018-07-01

Receive Date

2020-02-17

Publish Date

2018-07-01

Page Start

275

Page End

283

Print ISSN

1110-6751

Online ISSN

2682-3314

Article File

AJDSM_Volume 21_Issue 3_Pages 275-283.pdf

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https://ajdsm.journals.ekb.eg/article_71571.html

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https://ajdsm.journals.ekb.eg/service?article_code=71571

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Original Article

Type Code

848

Publication Type

Journal

Publication Title

Al-Azhar Journal of Dental Science

Publication Link

https://ajdsm.journals.ekb.eg/

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Article

Created At

22 Jan 2023