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71527

Evaluation of pilocarpine potentiality to counteract the rat parotid gland structural alterations induced by gamma irradiation

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Last updated: 22 Jan 2023

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Abstract

The effect of pilocarpine on irradiation induced rat parotid gland structural alterations was evaluated in 45 adult male Sprague- Dawley rats used in this study and they were divided into three groups,15 rats each. The control group rats did not expose to pilocarpine not radiation. The experimental group II rats were irradiated while those of group III were primarily treated by pilocarpine before irradiation. At 1,4 and 16 weeks after irradiation exposure, 5 rats from each group were euthanasially decapitated. Then the parotid glands were carefully dissected out and prepared for stain by hematoxylin and eosin stain. The histological examination showed that radiation induced harmful effects on the parotid gland were significantly reduced with pilocarpine. Conclusion: Pilocarpine, the parasympathomimetic agonist known to stimulate the various exocrine glands, has considerable improvement for the injurious radiation effects on salivary glands.

DOI

10.21608/ajdsm.2018.71527

Authors

First Name

Said

Last Name

M. Hani

MiddleName

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Affiliation

Professor of Oral Histology and Pathology, Oral biology department, faculty of dental medicine, Azhar University.

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First Name

Abd Elnasser

Last Name

A. Elmawla

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Affiliation

Assistant Professor of Oral histology, Oral biology department, faculty of dental medicine, Al-Azhar University.

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Orcid

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First Name

Ashraf

Last Name

M. Emran

MiddleName

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Affiliation

Demonstrator of oral histology, Oral Biology Department, faculty of dental medicine, Al-Azhar University

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Orcid

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First Name

Salwa

Last Name

F. Ahmed

MiddleName

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Affiliation

Lecture in Health Radiation Research Department, National Center for Radiation Research and Technology

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Orcid

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Volume

21

Article Issue

3

Related Issue

10890

Issue Date

2018-07-01

Receive Date

2020-02-17

Publish Date

2018-07-01

Page Start

221

Page End

227

Print ISSN

1110-6751

Online ISSN

2682-3314

Article File

AJDSM_Volume 21_Issue 3_Pages 221-227.pdf

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https://ajdsm.journals.ekb.eg/article_71527.html

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https://ajdsm.journals.ekb.eg/service?article_code=71527

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Original Article

Type Code

848

Publication Type

Journal

Publication Title

Al-Azhar Journal of Dental Science

Publication Link

https://ajdsm.journals.ekb.eg/

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Article

Created At

22 Jan 2023