The caries infiltration technique was introduced with the aim of filling the intercrystalline spaces with a low-viscosity resin, to arrest lesions and treat the esthetic problem of white spot lesions. This study was designed to evaluate the effect and clinical efficacy of resin infiltration technique on masking of enamel white spot lesions compared to an ordinary adhesive system. Methods: A total number of 20 patients having 120 not cavitated anterior teeth with white spot lesions were subjected to this study. After scaling, polishing and oral hygiene measures, the six maxillary anterior teeth were isolated with rubber dam. The teeth were divided into two groups, the first group (central incisor, lateral incisor and canine on right side of patient) was treated with hydrochloric acid (Icon-Etch) then ethanol (Icon-Dry) followed with application of resin (Icon-Infiltrant), while the second group: (central incisor, lateral incisor and canine on left side of the same patient) was treated with phosphoric acid (N-Etch) and adhesive (ExciTE F).Durability of used resins were clinically assessed by six of the FDI World Dental Federation criteria which were selected to be suitable for the current study (Surface luster, Surface Staining, Postoperative hyper-sensitivity, Recurrence of caries, Adjacent mucosa, and Patient's view), Each property has five grades from excellent to poor. Results: Both of treated groups showed improved surface luster, decreased postoperative hypersensitivity, diminished recurrent caries and increased patient satisfaction. Icon resin infiltration was more durable than Excite F adhesive after one year follow up. Both groups showed no initial surface staining, but with timesurface stainingbeing more with icon infiltrated group. Both materials have no effect on adjacent mucosa at different aging times. Conclusions: Icon resin infiltration is an effective treatment for deminiralized white spot lesions but with frequent repolishing to overcome surface staining for long lasting esthetic outcome. Excite F adhesive can be used only for short time sealing of enamel surface to improve the esthetics of white spot lesions and control of caries progression.