The caries infiltration technique was introduced with the aim of filling the intercrystalline spaces with a low-viscosity resin, to arrest lesions and treat the esthetic problem of white spot lesions. This study was designed to evaluate the color effect and durability of resin infiltration technique on masking of enamel white spot lesions compared to an ordinary adhesive system. Methods: a total number of 20 patients having 120 not cavitated anterior teeth with white spot lesions were subjected to this study. The six maxillary anterior teeth were isolated with rubber dam. The teeth were divided into two groups, the first group (central incisor, lateral incisor and canine on right side of patient) was treated with hydrochloric acid (Icon-Etch) then ethanol (Icon-Dry) followed with application of resin (Icon-Infiltrate), while the second group: (central incisor, lateral incisor and canine on left side of the same patient) was treated with phosphoric acid (N-Etch) and adhesive (ExciTE F).Evaluation of color was done using VITA Easyshade V (VITA Germany) at the following intervals (pre-operative, immediate, one week, three months, six months and twelve months post-operatively). Results: the highest mean value of color change was found immediately post-operatively for icon resin infiltration group presented as positive (ΔL) and negative (ΔC) that means decrease in the whitish discoloration of teeth. Conclusions: Icon resin infiltration is an effective treatment for deminiralized white spot lesions, while Excite F adhesive can be used for short time sealing of enamel surface to improve the esthetics of white spot lesions.