New natural products for agricultural uses are currently being developed from plants, such as plant extracts and vermicompost-tea, which help crops grow better and high productivity. The present research aims to evaluate the response of the lettuce plant to several biostimulants products. This experiment was carried out during the two successive seasons of 2018/2019 and 2019/2020 at Vegetable Private Farm at Kafr El-Sinhab, Mansoura Distract, Dakahlia Governorate, Egypt,to study the effect of some vermicompost-tea concentrations (5, 10 and 20%) used as soil application and some nature botanical extractsi.e. Rosemary leaf extract (RLE) and Eucalyptus buds extract (EBE) used as foliar sprayon lettuce head parameters, as well as physio-biochemical properties. Either vermicompost-tea or plant extracts increasedhead parameters (fresh weight, dry weight and head diameter), macro nutrient; N, P, K, micro nutrient; Fe, Zn, Mn and carbohydrate faction (total carbohydrate, total sugar and reducing sugar) in lettuce plants compared to those in theuntreated control plants. The interactive vermicompost-tea (20%) ×RLE application was the mosteffective forincreasind the abovementioned criteria.