The effect of sublethal concentration of tested compounds on some biological aspects of the cotton leaf worm, Spodopteralittoralisunder laboratory were evaluated. There were significant differences between tested compounds, Chlorpyrifos, alpha cypermethrin, spinosad, B. thuringiensisand orange oil and control in the larval duration period of the second and fourth instar larvae of cotton leaf worm, Spodopteralittoralis. As for,  larval mortality,chlorpyrifos was the most toxic compoundonsecond  and fourth  instar larvae of S. littoralis, recording 53.33 and 50.0%, respectively. There were significant differences between tested compounds and control on pre- pupalperiod,Pupal Pupation% andPupal weight (g) of second and fourth instar larvae of cotton leaf worm, Spodopteralittoralis. Chlorpyrifos recording the highestPupal duration 15.00 and 12 day compared with other tested compounds and control on second and fourth instar larvae of cotton leaf worm, S. littoralis. There were significant differences between tested compounds and control on adult emergence (%), sex ratio and male longevityin second and fourth instar larvae of cotton leaf worm, S. littoralis. On the other hand, there were significant differences between tested compound and control except Alpha Cypermethrin and Orange oil in second instar larvae of S. littoralis and Chlorpyrifos and B. thuringiensisin fourthinstar larvae of S. littoralis. As fornumber of eggs/female,fertility, hatchability (%) and deformation (%),Chlorpyrifosrecorded the best results in these items.