The aim of the present study was to investigate the following aspects; efficiency of abamectin alone or in binary mixtures with mineral oil and fertilizer against spider mite, Tetranychus urticae individuals, effect of adding mineral oil and fertilizer on physico-chemical properties of abamectin, residues determination of abamectin in cucumber fruits and effect of abamectin on yield of cucumber. The results show there were significant differences between treatments during two successive seasons, also, the results clear that adding fertilizer to mineral oil increasing efficiency. Regarding the results in case of 2017 summer season, the results with initial effect cleared that, mineral oil mixed with fertilizer recorded 62.0% reduction in individuals of Tetranychus urticae followed by abamectin alone, abamectin with mineral oil, mineral oil, abamectin with fertilizer and fertilizer. The same trend occurs in state of residual effect. The initial effect after 2^nd spray during 2017, summer season, outcomes clear that adding mineral oil to abamectin cause increasing efficiency to (67.5%) compared with abamectin alone (63%), while, the other treatments ranged between 25 to 52%. The same trend occure in state of residual effect. Also, the results illustrated that abamectin has high effective recorded (95.5%) in 2018 summer season after first spray. while, in case of the residual effect, it was found that adding fertilizer to abamectin reduce abamectin degradation, whereas recorded (96.3%) reduction. In case of yield, the treatments cause increasing in yield ranged between 5.1 to 61.9%. In case of physico-chemical properties, the results indicated that PH values ranged between 3.0 to 6.4, from high acidic to slightly acidic. Addition of fertilizer or mineral oil to abamectin cause increasing surface tension compared with abamectin alone (33.7, 40.6 compared with 31.06 dyn/cm). Also, the results showed that abamectin as acaricide completely disapperd in each treatment in the 12^th day of application. The fruits of cucumber are edible in the 6^th day after spray where the residues of abamectin were less than MRL (0.5)mg/kg^-1. The half life periods (T 1/2) were increased when addition mineral oil and fertilizer to abamectin.