On- farm field experiments were conducted to assess the impacts of some nitrogen (N) and phosphorus (P) bio-chemical fertilization regimes on wheat grain yield and its components and harvest index of wheat cultivar Misr-1. Experiments were conducted in a farmer's field, El-Sheikh Essa Viallage, Zagazig District, Sharkia Governorate, Egypt, during the two successive winter seasons of 2012-2013 and 2013-2014. The five nitrogen fertilization regimes (NFR) studied were (control ; 100 kg N/fad.; 75 kg N/fad. + cerealine; 50 kg N/fad.+ cerealine; cerealine) as well, the seven phosphorus fertilization regimes (PFR) studied were (control; 15 kg P2O5/fad.; phosphorien; mycorrhiza; 7.5 kg P2O5/fad. + phosphorien ; 7.5 kg P2O5/fad. + mycorrhiza ; phosphorien + mycorrhiza). Regarding the impact of (NFR), results show that, whatever the NFR applied, it caused significant increase over the control in each of spike No./m2, grain weight/spike, grain No./spike, 1000-grain weight, grain yield/fad., and harvest index. The appliance of the dual bio-chemical fertilizers i.e., (75 kg N/fad.+ cerealine) ranked at the top in grain yield/fad., and the main components i.e. spike number/m2, grain weight/spike, 1000-grain weight. As for PFR, results revealed that availability of phosphorus via the application of any PFR surpassed the control in each of spike No./m2, 1000-grain weight, harvest index and grain yield/fad. The PFR which included both chemical and bio-fertilizers i.e. (7.5 kg P2O5/ fad. + phosphorien) outyielded other PFR, and was excellency in each of spike No./m2, grain weight/spike, grain number/spike and harvest index.