A field experiment was carried out for two successive winter seasons at Ismailia Agric. Res. Station in Ismailia Governorate, Egypt to evaluate possibility of using vinasse in combination with some organic acids for improving nutrients status of the sandy soil and its reflection on wheat (Giza 168) yield productivity. The experiment was laid out in split plot design, with three replicates. the main plots included five treatments including control (recommended NPK. dose), vinasse (V), vinasse and humic acid (VH), vinasse and fulvic acid (VF), vinasse and humic substances (VHS). The sub-main plots represented treatments with different rates of 0, 20, 30 and 40 liters faddan^-1. All treatments were sprayed on the sandy soil three times at 30, 45 and 60 days from shown during two cultivated seasons. Results revealed that wheat yield (straw and grains) along with total content of N, P and K generally increased significantly in response to vinasse and fulvic acid (VF) treatment as compared to either control or other treatments. Moreover, values of wheat plant increased by increasing vinasse application in combination with different forms of organic acid as compared to either applied vinasse alone or control treatments; the superior rate was 40 L faddan^-1. On the other hand, the application of some organic conditioners slightly decreased both pH and EC values as compared to control treatment. Relatively different trend was observed with organic matter and saturation percent which increased in all treatments as compared to control treatment. Also, available NPK in soil were also increased gradually by increasing rate of organic conditioners. In conclusion, application of vinasse combined with other organic acids (humic, fulvic and humic substances) generally enhanced wheat yield productivity, total content of macronutrients in both straw and grains along with improved some chemical properties of sandy soil under investigation.