The present investigation was carried out in a private apiary located at Abu-Hammad District, Sharkia Governorate during 2017 and 2018 seasons. The study aimed to evaluate the effect (suitability) of four veterinarian food additive formulations on the performance of honeybee colonies. Summarized results showed that feeding honeybee colonies on sucrose syrup (1:1) enriched with the food additive formulations AD3H, VIGO I. Sel, VIGO mino vit and VIGO-FLU caused noticeable increase in colonies activities, that recorded 13.0, 9.0, 9.8 and 8.0% over the control in the area of sealed brood reared; 37.50, 1.09, 26.20 and 62.35% in drawn area of wax foundation; 26.9, 108.6, 27.8 and 100.2% in the hoarded amount of fortified syrup and 51.72,8.62,49.13 and 46.55% in clover honey yield for the four tested formulations, respectively.