Ismailia Canal is one of the most important branches of the Nile River in Egypt. It is the main source of drinking and irrigation water for many cities. Water and sediments samples were taken from 6 sites during 6 months of (Jan., Mar., May, July, Sept. and Nov.) 2017. The sites are: (I) El-Mazalat (at start of the canal), (II) Al- Ameriyah, (III) Mostourd, (IV) Abu-Zaabl, (V) Al-Monair and (VI) Belbies. The samples of water and sediments were chemically analyzed for detection of heavy metals i.e., (Cu, Pb, Cd, Ni and Zn). Abu-Zaabl site was more pollution than the other sites. The contents in water were within the limits allowed by the World Health Organization (WHO, 1995). Highest pollutions were sites III, IV and V.