The present work was designed to investigate the potential of using plantain (Plantago major L.) for the phytoremediation of pymetrozine contaminated soil. The use of soluble silicon dioxide (SiO₂), Tween 80, hydroxypropyl-β-cyclodextrin (HPβCD) and liquid humic acid (HA) for enhancing the availability and uptake of pymetrozine contaminated soil by P. major were evaluated.Results revealed thatpymetrozine concentrations in soil with P. major reduced by 30.00 – 83.25% throughout 1 to 12 days exposure, compared with 12.50–61.90% in the soil of control. Pymetrozine uptake in the roots and translocated in the leaves of P. major to reach the maximum levels, 53.41 mg/kg and 58.08 mg/kg, respectively, after 4 days. The phytoremediation efficiency of P. major amended with SiO₂ was greater than that of other solubility-enhancing agents with respect to the removal of pymetrozine from contaminated soil within 1-12 days of treatment. The addition of SiO₂ increased pymetrozine uptake in roots and translocation in leaves by about 170.84% and 322.83% compared with P. major roots and leaves alone, respectively within 4 days. The most-effective to least-effective supplements to use in combination with P. major for the purpose of pymetrozine phytoremediation in roots and leaves were found to be as follows: SiO₂> HA > HPβCD > Tween 80. This study indicates that SiO₂ can improve the efficiency of phytoremediation of pymetrozine.