Field experiment was conducted to investigate the efficiency of pre-emergence herbicide, Gesaprim and it's mixtures with some materials on mineral contents, growth, and residual effect of Gesaprim on soil of maize plants during 2015 and 2016 growing seasons in Sharkia Governorate. Gesaprim (G) was added at the rate of 750 g/fad., and the other materials e.g. ammonion sulphate (N), phosphoric acid (P), potassium sulphate (K) and Tween-40 (S), as a surfactant were added at the rate of 215.35, 243.89, 215.38 g and 54.84 cm3/fad., respectively. Results revealed that the herbicide Gesaprim with mixed materials gave wide range on the vegetative growth, mineral contents and residual effects in maize plants. Results showed that, average of mineral content in maize leaves from the investigated elements [(nitrogen (N), phosphorus (P), potassium (K), calcium (Ca) and sodium (Na))] were as follows: 1.160, 0.322, 1.784, 0.240 and 0.614 for Gesaprim only; while they were 1.074, 0.413, 1.605, 0.244 and 0.604 for surfactant only; meanwhile, averages were 1.184, 0.346, 1.760, 0.245 and 0.616 for the treatment of Gesaprim+surfactant; meanwhile, for the treatment of Gesaprim + ammonium sulphate, they were 1.251, 0.322, 1.674, 0.245 and 0.594 (%). Also, they were 1.124, 0.409, 1.593, 0.251 and 0.581 for the treatment of Gesaprim + phosphoric acid. For the treatment of Gesaprim + potassium sulphate, the averages were 1.138, 0.284, 1.802, 0.260 and 0.564 while average of mineral contents were 1.151, 0.667, 1.689, 0.246 and 0.584 for the treatment of hand weeding. As for control, the averages were 1.246, 0.876, 1.700, 0.237 and 0.429. Results revealed that in vegetative growth, all the treatments of Gesaprim with materials had stimulatory effect on the fresh weight of shoots expect Gesaprim alone and Gesaprim combined with potassium sulphate. While the dry weight of shoots in case of, Gesaprim alone and Gesaprim combined with materials had stimulatory effect. The residual amounts of Gesaprim mixed with materials were 5.289, 3.478, 3.627; 4.565, 3.720, 0.00; 12.332, 2.017, 5.591; 3.578, 4.085, 5.611 and 3.435, 5.745, 5.405 at 5, 7 and 20 days after treatments by Gesaprim, G + S , G + N , G + P and G+ K , respectively.