This work was carried out in a Private Farm at Awlad Saqr District, Sharkia Governorate, Egypt during two successive summer seasons of 2016 and 2017 to study the effect of mineral fertilizers (NPK), organic fertilizer in the form of poultry manure (PM) and bio-fertilizer (Nitrobein, Phosphorein and Potassiumag) each alone and their mixture on dry weight parameters, flowering, fruit set and yield and its components of some tomato hybrids grown under high temperature conditions. The experimental design was split plots with three replicates included 14 treatments. Two different tomato hybrids were used included. Alia123 (V1) and Rama888 (V2)were randomly distributed in the main plots and 7 fertilization treatments [100%mineral fertilizers (T1), 100% bio-fertilizers (T2), 100% organic (T3), 100% mineral+100% organic manure + 100% bio-fertilizer (T4), 75% mineral + 100% organic manure + 100% bio-fertilizer (T5), 50% mineral + 100% organic manure + 100% bio-fertilizer (T6) and 25% mineral + 100% organic manure + 100% bio-fertilizer (T7)] were arranged in sub plots. Results showed that dry weight of shoots per plant and total dry in Alia123 (V1) hybrid significantly increased. While Rama888 hybrid (V2) significantly enhanced flowering, fruit set characters, as well as yield and its components. Moreover, 100% mineral + 100% organic manure + 100% bio-fertilizer (T4) significantly improved all dry weight parameters. Also the same treatment significantly increased flowering, fruit set characters and yield and its components. Furthermore, using Alia123 (V1) hybrid with mixture of 100% mineral + 100% organic fertilizer + 100% bio-fertilizer (T4) significantly enhanced all dry weight parameters. While using Rama 888 hybrid (V2) with a mixture of 100% mineral + 100% organic fertilizer + 100% bio-fertilizer (T4) were the superior interaction treatment which reflected a significant effect on all flowering and fruit set characters, as well as yield and its components. Generally the both hybrids were recorded good results for sowing under high temperature conditions in most cases.