Factorial design experiment (7×2) was carried out including seven levels of Azzawi date waste meal, DWM (0, 5, 10, 15, 20, 25 and 30% of the diet as replacement of yellow corn) and two levels of supplemented Avizyme (0.0 or 0.1 g/kg diet). A total number of 420 unsexed one week old quail chicks, were randomly distributed into fourteen treatment groups, each of 30 chicks, with three replicates each of 10 chicks. Each experiment group was allotted on one of the experimental diets to study the effect of Azzawi date waste  meal (DWM) in the diet with or without Avizyme supplementation on the growth performance (live body weight, body weight gain, feed consumption and feed conversion) of growing Japanese quail. Results obtained showed that, chicks fed diets containing DWM up to 30% improved significantly (P<0.01) live body weight at 6 weeks of age, body weight gain during, 3-5 and 1-5 weeks of age as compared to the control group, Feed consumption was insignificantly increased during 1-3 and 1-5  weeks of age  by increasing DWM levels in the diets up to 20%, increasing DWM levels from 20 to 25 or 30% resulted significant (P< 0.01) increase in feed consumption compared with control and other dietary treatment groups. Feed conversion during all the experimental periods were not significantly affected due to DWM incorporation up to 20% compared to control. While increasing DWM levels from 20 to 25 or 30% resulted significant (P< 0.01) increase (poorest) in feed conversion compared with control and other dietary treatment groups. Enzyme supplementation of the experimental diets significantly (P ≤ 0.01) improved live body weight at 5 weeks of age and body weight gain through the whole experimental period (1-5 weeks of age) compared with those fed unsupplemented one. While, feed intake and feed conversion insignificantly affected as the diets were supplemented with avizyme. The highest live body weight and body weight gain were recorded for chicks fed diet containing 30% DWM with avizyme supplementation. In conclusion, it could be concluded that, DWM could be used in Japanese quail diets up to 30% with enzyme supplementation (1 g/kg diet) without adverse effect on their growth performance.