Wheat fields in Egypt are spatially variable as to soil fertility and crop productivity. The general objective of this study is to determine the relationships between yield, mineral content of wheat with N, P and iron foliar spray rates using the regression analysis of yield data. The study was carried out using N application (190, 285 and 380 Kg N ha^-1), P application (0, 15, 31 and 47 Kg P ha^-1) and iron foliar spray (without, mineral iron and chelated iron at 0.2 gl^-1). Wheat (Triticum aestivum, Giza 168 cultivar) was grown at research station of the Desert Research Center, El Quntra Sharq, Eastren North Sinai, Egypt in the 2015-2016 season. The highest grain and straw yields were obtained under 285 Kg N + chelated iron and 31 Kg P ha^-1. The highest wheat grain nitrogen uptake was obtained under 285 Kg N + chelated iron and 31 Kg P ha^-1. The highest N uptake by wheat straw was obtained under 285 Kg N + chelated iron and 47 Kg P ha^-1. The highest P uptake in grains was obtained under 380 kg N ha^-1 + mineral iron and 31 Kg P ha^-1. The highest P uptake in straw was obtained under 285 Kg N ha^-1 + chelated iron and 31 Kg P ha^-1. The highest Fe uptake in grains was obtained under 285 Kg N ha^-1 + mineral iron and 47 Kg P ha^-1. The highest Fe uptake in straw was obtained under 285 Kg N ha^-1 + mineral iron and 47 Kg P ha^-1.