This study was conducted at Ismailia Governorate, Egypt. The investigation aimed to evaluate physicochemical characteristics of two mango cultivars i.e., Ewais and Zebda (Mangifera indica L.). Mango trees, 10 years old (planting distance 7 × 7 m) from each cultivar were selected to be nearly size and being in their off bearing. Leaves at different stages of growth and fruits were investigated. Results revealed that, Ewais leaves have  phenolic compounds from 80.36 to 92.82 (mg ̸ gfw), Cytokinin from 3.60 to 4.41 (ng/gfw), gibberilic acid from 28.58 to 36.61 (µg/gfw), absisic acid from 8.44 to 9.5 (µg/gfw), total protein from 4.38 to 9.13(g ̸ 100 gdw), total free amino acids  from 23.72 to 36.70 (m mol ̸ 100 gdw), total protein  from 5.83 to 7.22 (µmol ̸gfw), total carbohydrate  from 18.76 to 21.09 (g ̸100gdw), total chlorophyll from 1.55 to 2.11 (mg/gfw) and total carotenoid from 0.82 to 0.98 (mg/gfw). Enzymes activities (mmol ̸ gfw) in Ewais leaves were as follow, catalase between 26.23 and 50.31, peroxidase between 1.23 and 2.80, polyphednol oxidase from 101 .29 to 106.62 and amylase from 7.13 to 8.1. These results dependant on growth stages and were superior for Zebda cultivar. Ewais cultivar has higher yield (yield ̸ tree, kg) (92.82) than zebda (89.27). Fruits of Ewais have a higher performance parameters than fruits of Zebda.