The current study sought to investigate the influence of individual and combined in different levels of natural products (aqueous extract of Hibiscus rosa-sinensis leaves-AEHRS, aqueous extract of pomegranate (punica granatum) peels-AEPP- and mixture of both) in order to assess the potency of the previous aqueous natural products extracts against liver diseases (oxidative stress). The serum aspartate aminotransferase (AST); alanine aminotransferase (ALT); alkaline phosphatase (ALP) and total bilirubin were assayed after 7, 14 and 21 days. Male albino rats were used in this study which contained twelve groups, six animals each. Group (I) normal control without any extract of AEHRS leaves or AEPP. Group (II) injected with carbon tetrachloride(CCl₄) induced oxidative stress in rats (CCl₄  control-treated group).Groups (III)leaves extract 250 mg/kg b.wt. of HRS, (IV) leaves extract 500 mg/kg b.wt. of HRS, (V) leaves extract 750 mg/kg b.wt. of HRS, (VI) peels extract 100 mg/kg b.wt. of P.granatum, (VII) peels extract 200 mg/kg b.wt. of P.granatum, (VIII) peels extract 300 mg/kg b.wt. of P.granatum, (IX) AEHRS leaves and AEPP mixture 125/125 mg/kg b.wt. (X) AEHRS leaves and AEPP mixture 225/225 mg/kg b.wt, (XI) AEHRS leaves and AEPP mixture 350/350 mg/kg b.wt .In addition, one group for carbon tetrachloride rats group which treated with AEHRS leaves and AEPP mixture 400/400 mg/kg b.wt (XII), respectively. All groups were received the extracts daily oral except for normal control group (I). The present data demonstrate that AEHRS leaves, AEPP and their mixtures significantly attenuated liver functions parameters in serum when comparing with normal control group (I) and intoxicated control group (II). These findings suggest that AEHRS leaves, AEPP and mixtures of both have a potent hepatoprotective effect, where ALT, AST, ALP and total bilirubin decreased from 29.55± 1.15 to 20.15±0.87U/l, from 47.97±1.66 to 30.99±1.78U/l, from 305.96±35.61 to 170.55±46.42 U/l and from 3.11±0.02 to 2.21± 0.81mg/dl respectively.