A5×2 factorial design experiment, included five levels of dried distillers grains by soluble, DDGS, (0, 7.5, 15, 22.5 and 30% in the diet) and two levels of enzyme supplementation (without and 0.5 g enzyme/kg diet) through 1-9 weeks of the age. A total number of 300 Saso broiler chicks one week old were randomly divided into 10 treatment groups each of 30 chicks, with three replicates each of 10 chicks. Each experiment group was allotted on one of the experimental diets to study the effect of DDGS in the diet with or without Avizyme supplementation on growth performance (live body weight, body weight gain, feed consumption and feed conversion) of Saso broiler. The results indicated that no significant effects of DDGS levels were detected on body weight (BW) at all studied ages (1, 5 and 9 weeks of age). Body weight gain (BWG) was significantly (P>0.05) affected due to DDGS levels only at the period of 5-9 weeks of age. It is worth noting that, the best BWG was found in 22.5% DDGS group (29.20 g/day), followed by that of 30% DDGS (27.67 g/day) compared with the control and the other DDGS levels. Chicks fed the 30% DDGS diet consumed more feed compared with the control and other DDGS levels. During the period of 1-5 weeks of age, the best feed conservation ratio (FCR) (1.75) was found in 7.5% DDGS group. While, the group of 22.5% DDGS gave the best FCR value (3.15) during 5-9 weeks of age. Results noticed that chicks fed diets supplemented with Avizyme gained more weight compared to those fed unsupplemented diet. Results showed that, feed intake was insignificantly effected during all experimental periods studied, while feed conversion was significantly (P>0.05) improved due to Avizyme supplementation during 5-9 and 1-9 weeks of age compared to the control. The interaction between DDGS levels and enzyme supplementation was significant (P>0.05) on BW at 5 weeks of age, BWG and FC at the first period (1-5 weeks of age). Chicks fed diet contained 22.5% DDGS supplemented with enzyme improved values of live body weight at 9 weeks of age, body weight gain and FC during all the experimental periods. In conclusion it could be concluded that, DDGS could be used in Saso broiler diets up to 22.5% with enzyme supplementation (0.5 g/kg diet) without adverse effect on their growth performance.