The aim of this study was to evaluate some physiological parameters and biochemical changes in common bean plants (Phaseolus vulgaris) as a result of the foliar spraying of some nano stimulants (silicon, polyamine, seaweed and biofertilizer) under salt stress conditions. The pot experiment was conducted in the Agriculture Faculty's greenhouse at Menoufia University in Shibin El-Kom, Egypt during the two summer seasons of 2019 and 2020. Salt stress at level 6 dS/m significantly decreased growth, physiological characteristics, photosynthetic pigments, chemical measurements, and yield parameters. Meanwhile, the use of nano stimulators reduced the adverse effects of salinity by improving water relations, chlorophyll, enzymatic antioxidants (peroxidase and polyphenoloxidase), non-enzymatic antioxidants defense system (carotene, total soluble sugars, total amino acids, and proline), N, P and K and decreased Na+ concentrations resulted in high seed yield, particularly with nano silicon followed by nano biofertilizer. As the level of salinity increased, the seed weight (g/plant) decreased significantly by about 40% at the salt level 6 dS/m. In comparison to the control, using nano silicon resulted in significant increases in the leaf area, relative water content, proline concentration and seed weight by about 84, 53, 49 and 91%, respectively at 6 dS/m salinity level. To mitigate the negative impacts of salinity and improve the production, this study suggests spraying common bean plants with nano silicon followed by nano biofertilizer.