The was aimed to evaluate the efficacy of commercial product, Xan-Tari (Bacillus thuringiensis) at different concentrations against O. surinamensis and S. granaries adults showed that mortality increased by increasing the Xan-Tari concentration,period exposure and temperature for both insect species. Highest mortality took place at 25 and 30°C .  for  O. surinamensis . The highest mortality recorded against  S. granaries occurred when treatments took place at 25°C . The results indicated that S. granarius was  more succeptible to Xan-Tari treatment  than O. surinamensis  . The safety of  Xan-Tari (Bacillus thuringiensis)on mammals was investigated  by determining the toxicological effects on liver and kidney enzyme activities and its oxidative stress in male albino rats. In this study, 20 male albino rats (western strain) were divided into 2 groups, each of one 10 rats. First group kept was control,while the second  was fed on diat of 400 g of wheat mixed well with Xan-Tari. It was administrated one time per day to the rats for 3 successive weeks   quantity of food consumed rat  averaged from 25 - 30 gm. The obtained results showed significant  increase  in ALT, AST, creatinine, urea, uric acid, CAT, MDA and GSH in treated rats .