The main aim of this research is to study the effect of different soilless systems (aeroponic and substrate) on nutrients and water apply rate of potato plant to achieve that study, the effect of different soilless systems (aeroponic and substrate) on nutrients and water apply rate during experimental period. Also fresh and dry weight of shoot, roots and tubers were studied at the end of experimental period. The obtained results indicate that the total nitrogen, phosphorus , potassium, calcium, magnesium apply rates were 42.24, 43.53 and 39.24, 18.34, 19.88 and 10.18, 31.69, 32.99 and 33.98, 27.63, 29.35 and 29.35, 24.1, 25.53 and 7.35 mg plant^-1 for T1,T2 and T3 ,respectively. The water apply were 74.49, 79.48 and 61.90 L plant^-1 for T1, T2 and T3, respectively. The fresh and dry weight of shoot and roots were increased in aeroponic system better than those of substrate system. The fresh and dry weights of tubers were 294.46, 44.56, 255.15, 42.15 and 227.3, 40.3 g plant^-1 for T1, T2 and T3 respectively. The average water use efficiency were 22.95, 25.65 and 10.63 Kg m^-3 for T1, T2and T3, respectively.