The effect of methomyl and copper sulphate on Eobania vermiculta and Helicella vestalis snails under laboratory and filed conditions was evaluated at Sharkia Governorate. Results under laboratory conditions revealed that, mortality percentages increased with increasing the concentration values and the duration of exposure. All  concentrations of methomyl, exhibiting the highest mortality percentages for Eobania vermiculata where recorded 85, 92.5 , 100 and 100% with 1, 3, 5 and 7% concentrations   after 7 days post-treatment, while the parallel values of copper sulphate were recorded 65, 70, 80 and 85%,  respectively.  It noticed that the concentrations of methomyl were more effective against H. vestalis snail were recorded 100-100% mortality comparing with the same concentrations of copper sulphate which recorded 47.6- 72.5% mortality 7 days post-treatment, respectively. Regarding field experiment it noticed that the initial reduction percentages for two tested compounds were very low where gave 7.55 and 1.13 % for methomyl and copper sulphate against E. vermiculata snail, respectively. The residual effect of the tested compounds was 47.77 and 7.74 % for methomyl and copper sulphate, respectively.