The present study aimed to throw light on the efficiency of two insecticides, Azadirachtin and Emamectin Benzoate.Chemical components of serum blood andhistopathological were examined by three different doses treated orally (1/100, 1/150 and1/225 LD₅₀) of adult mature male albino rats weighting (100-120) g for 60 days. The results showed that there were significant increases ofALT,AST,urea and creatinine in the treatment of Azadirachtin more than Emamectin Benzoate and control. On the other hand there were significant decreses in protein content in the treatment of Azadirachtin more than Emamectin Benzoate on comparision with control. Histological studies were certain of chemical analysis results.At the end all the results indicated the toxic nature of the Azadirachtin insecticide were more than Emamectin Benzoate on albino rats.