These experiments were carried out at Menya AL- Qamh district, Sharkia governorate, during two growing seasons of 2016 and 2017 cucumber, Cucumis sativus plants. Varieties Sahim - El-prince and  Beit alpha were planted to study their infestation with some pests aphid, leafhopper, mite, whitefly and thrips and the relationship between some chemical contents (Lipids , carbohydrate, protein and pH values) of the varieties and their infestation by Aphis gossypii (Glov.), Empoasca decipiens (Paoli) Empoascya decedens (Paoli). Bemesia tabaci (Genn.), Tetranychus cucurbitacearum  (Sayeg),   and Thrips tabaci (Lind).The obtained results showed that the susceptibilty of cucumber varieties to pest infestation could be arranged descendingly according to the number of pests as follows: Beit alpha, El -prince and  Sahim. Chemical analysis results indicated the increase in protein and carbohydrate contents caused on increased the mean number of some pests infested these varieties cucumber, while studied those increase of pH values led to decrease the mean number of pests and their rate of infestation.