This study was conducted throughout the two successive seasons of 2017 and 2018 at Fruit Nursery of Horticulture Department, Faculty of Agriculture at Moshtohor, Benha University Qalyubeia Governorate, Egypt., to study the impact of NPK bio fertilization application on different growth parameters of Manfaloty and Wonderful  pomegranate transplants at one-year- old. The eight treatments involved in this study were summarized as follows: T1-recommended doses (RD) , T2-RD NPK mineral fertilizers + Soil application of  Nitrobene at 5 ml/ transplant,T3-RD NPK mineral fertilizers + Soil application of  Nitrobene at 10 ml/ transplant, T4-RD NPK mineral fertilizers + Soil application of  Phosphorene  at 5 ml/ transplant,T5-RD NPK mineral fertilizers + Soil application of  Phosphorene  at 10 ml/ transplant, T6  -RD NPK mineral fertilizers + Soil application of  Potasene  at 5 ml/ transplant,T7-       RD NPK mineral fertilizers + Soil application of  Potasene  at 10 ml/ transplant and T8 RD NPK mineral fertilizers + Nitrobene at 5 ml + Phosphorene at 5 ml / + Potasene at 5 ml / transplant.The result indicated that, application of T8 (RD NPK mineral fertilizers + Nitrobene at 5 ml + Phosphorene at 5 ml / + Potasene at 5 ml / transplant) caused a significant increasing in the rate of length, diameter, number of leaves, leaf area,transplant leaves area, fresh and dry weights.Moreover, T3 (RD NPK mineral fertilizers + Soil application of  Nitrobene at 10 ml/ transplant)ranked statistically second in this concern. On the contrary, the least values of the abovementioned parameters were usually in concomitant to T₁ - Control (recommended dose) which ranked statistically last during both seasons of study.