This study include 32 species all belonging to the genus Euphorbia ( Euphorbiaceae) .These samples collected from different floristic regions in Egypt. The anatomical studies occur on the stems of the plant samples and the characters are recorded comparatively for each species. The observations showed that the stems are mostly angled, the epidermis is often simple with one layer, the cortical layers of many species contained storage parenchyma, cells like palisade tissue. Transfer tissue, air cavities and idioblast also calcium oxalate observed in the cortex. The pith is solid in most samples and hollow in a few species.