Hibiscus rosa sinensis (HRS) leaves and pomegranate (punica granatum) peels (PP) have many medicinal applications. Effect of natural products (aqueous extract of Hibiscus rosa sinensis leaves (AEHRS leaves),pomegranate (punica granatum) peels (AEPP) and their mixture) on protein profile (total protein (TP), albumin (Alb) and albumin/globulin (A/G) ratio) concentrations at 7, 14 and 21 days of male albino rats was studied. Seventy two male albino rats were divided into twelve groups of six animals each (n=6). The first group served as the normal health control (I). Animals of the second group (II) were induced hyperglycemia (diabetic control group) by injection of 65 mg/kg bw of streptozotocin (STZ). Three groups (III, IV and V) were given hibiscus aqueous leaves extracts (AEHRS) orally daily, at doses of  250, 500 and 750 mg/kg bw respectively. Also, three groups (VI, VII and VIII) were given P. granatum aqueous peels extracts (AEPP) orally daily, at doses of 100, 200 and 300 mg/kg bw respectively. Finally, three groups those IX, X and XI were given mixture of AEHRS leaves and AEPP orally daily, at doses of (125/125,225/225 and 350/350 mg/kg bw). In addition, one of streptozotocin (STZ) rats group was treated with AEHRS leaves and AEPP mixture 400/400 mg/kg bw (XII) respectively. Serum was separated for estimation of total protein (TP) and albumin (alb) as well as albumin/globulin (A/G) ratio was calculated after 7, 14 and 21 days. Protein profile contents results showed different changes at all experimental periods which sometimes observed some increased or decreased values comparing with normal health control group (I) only but highly significant increase was obtained when compared to diabetic control group (II) only. In view of these facts the improving and protective effect of AEHRS leaves, AEPP and their mixture against male albino rats protein profile was showed.