According to the integrated mite management programs, laboratory experiments were carried out to evaluate the toxic effect of Three chemical compounds (Abamectin ; Fenpyroximate ;  Cypermethrin )and one plant extract ( Wormseed) against the egg and adult females of the two spotted spider mite Tetranychus urticae (Koch) and adult females of predatory mite Amblyseius gossipi (El-Badry) on two different host plants (Cotton and Soybean). The side effect of mentioned compounds on some biological aspects of two species of mites were also evaluated. Cypermethrin was the most effective compound tested on egg deposition of T. urticae on Cotton plant, while on the other host occupies the next position after Fenpyroximate. Also, Cypermethrin was highly toxic compound that caused the highest decrease in egg hatchability especially on Cotton and Soybean.According to the nature of the chemical the prey egg consumption by the predator changed depending on time elapsed between egg contamination by chemical and egg introduction to the predator, also consequently the predator egg production.While the data in the filed indicated that the same effects  Abamectin was the most effective compound while Fenpyroximate and Cypermethrin caused a moderate effective,but Wormseed caused the  least  effective compound to motile stages of T. urticae thanA. gossipi on tow different host plants (Cotton and Soybean).