Two field experiments were conducted during 2016 and 2017 seasons at Sids Agricultural Research Station to investigate the influence of foliar application of a commercial compound challenger (contain 20% K₂O, 15% N, 5%, P₂O₅, 2.5% Zn and 0.1% Fe, Mn, Mg)  on agronomic characters and some leaves chmical components of cotton Giza 95 cultivar. Two rates of the commercial compound  (0.75 g/L and 1.5 g/L) were used and sprayed on plants, at different stages of growth, i.e., start of squaring and start of flowering, start of squaring and peak of flowering, start of flowering and peak of flowering and start of squaring + start of flowering + peak of flowering. A randomized complete block design with four replecats was used in both seasons. The application of the commercial compound resulted in significant effect on leaves chemical composition (chlorophyll a, b and carotenoids)), growth characters (plant height, no. of fruiting branches/plant), earliness %, yield components (No. of open bolls/plant, boll weight, seed cotton yield, and seed index), while fiber properties did not affect. The best results were obtained under application of the commercial compound at the rate of 1.5 g/L three times, i.e., at squaring, beginning of flowering and peak of flowering, with no significant differences by using the commercial compound at the rate of 0.75 g/L three times.