Two field experiments were conducted at the Experiment and Research Center, Fac. Agric., Moshtohor, Benha Univ., during 2014/15 and 2015/16 seasons. The aim of this study was response to investigate the effect of three wheat varieties (Misr 2, Sakha 94 ,and Sids 12)to four  planting methods (prodcasting, rows,  hills on ridges and rows on beds ) and two application methods (prodcasting and drilling). The results indicated that: Misr 2 variety gave the highest values of plant height, spike length, No.  tillers and spikes m^-2, No.  spikelets spike^-1, weight of grains spike^-1 , biological and grain yields fed^-1 compared with the other varieties in the first and second seasons. planting by rows on bed method increased significantly  plant height, spike length, No. otillers and spikes m^-2, No. spikelets spike^-1, weight of grains spike^-1, 1000-grain weight, biological and grain yields fed^-1 compared with the other planting methods in the first and second seasons. Plant height, spike length, No.  tillers and spikes m^-2, No. spikelets spike^-1, weight of grains spike^-1, 1000-grain weight, biological and grain yields fed^-1 increased significantly by prodcasting N application method in the first and second seasons. Plant height, No. tillers and spikes m^-2, No.  spikelets spike^-1, weight of grains spike^-1, 1000-grain weight, biological and grain yields fed^-1 were affected by the interaction between wheat varieties and planting methods in the first and second seasons except 1000- grain weight in the second season. Plant height, No.  tillers and spikes m^-2, No.  spikelets spike^-1, 1000- grain weight and biological yield fed^-1 were affected by the interaction between varieties and nitrogen application methods in the first and second seasons except plant height and No.  spikelets spike^-1 in the first season. Plant height, No.  tillers and spikes m^-2, No.  spikelets spike^-1, biological and grain yields fed^-1 were affected by the interaction between planting methods and nitrogen application methods in the first and second seasons except plant height, No.  tillers m^-2, No.  spikelets spike^-1 and grain yield fed^-1 in the first season. Also, plant height, No.  tillers and spikes m^-2, weight of grains spike^-1, 1000-grain weight, biological and grain yields fed^-1  responded significant to the interaction of the three involved factors (varieties x planting methods x N application methods). It could be concluded that under the conditions of the experiment, planting Misr 2 var by rows on bed method under proadcasting N application is recommended.