Early detection of breast cancer is one of the most efficient prevention strategies. The purpose of this research is to find out more about the possible association between progression of pre-menopausal breast cancer and the underlying metabolic and physiological changes in blood samples, liver and kidney functions among Egyptian males at Zagazig University Hospitals. 60 pre-menopausal breast cancer patients treated and followed-up at clinical oncology & nuclear medicine department. Biochemical parameters including albumin, liver enzymes, urea, creatinine were measured in blood. Results showed a statistically no significant change in hemoglobin and RBCs count of breast cancer cases compared to their controls. Also, parameters of liver and kidney function tests was no discernible difference between the two research groups (P>0.05). on the other hand, We discovered a considerable rise in levels of ALT and AST enzymes in the blood of breast cancer patient compared with control while the levels of albumin showing no difference between patient and control. Finally, these observations declared that levels of albumin, creatinine and urea in blood could be ignored and this may save time, efforts and money in in prognosis of pre-menopausal cancer in clinical Oncology Units.