Prostate cancer is considered as the most commonly diagnosed cancer cause of death among men, reports in 2020 estimated that about 191, 930 were new cases with 33,330 expected to die of this disease. This elevating rate making it the second most commonly diagnosed cancer type in men. Early prognosis of prostate cancer can give hope for early recovery. But in clinical oncology units, diagnosis may be associated with different not specific physiological and biochemical measurements to make a decision. The aim of this study is to investigate the possible association progression of prostate cancer and the underlying metabolic and physiological changes in blood samples among Egyptian males at Zagazig University Hospitals. Fifty prostatic cancer patients treated and followed-up at clinical oncology & nuclear medicine department. Biochemical parameters including albumin, urea, creatinine were measured in blood. Results showed a statistically significant decrease of hemoglobin and RBCs count of prostate cancer cases compared to their controls (P=0.001 and 0.005) respectively, while other CBC parameters were statistically not significant between both groups (P>0.05). Other liver and kidney function tests showed no significant difference between the two studied groups (P>0.05).