Medicinal plants have been employed as medication all over the world Since ancient times. Thanks to years of dedication and commitment to research, scientists have made tremendous progress recently in discovering the plethora of therapeutic potentials of medicinal plants. Solanaceae is one of the most prestigious families as its species could be ranked at the top of the most important medicinal plants to human beings in many ways. Solanaceae contains countless bioactive compounds which are used to treat various diseases and disorders, which could be used as anticancer, antimicrobial, antioxidant agents, etc. Additionally, it has many industrial and nutritional benefits. It also gets the most attention from taxonomists because it contains various taxonomic characteristics. In this review, we will concisely display the most remarkable morphological characters, chemical composition, and therapeutic potentials of Solanaceae with a focus on four of the most essential species named Cestrum diurnum, Cestrum elegans, Cestrum nocturnum, and Cestrum parqui.