The emergence of types of bacteria resistant to antibiotics is a common and most dangerous problem in the current era. In this study, 50 samples from diabetic patients including diabetic foot (n = 36), wounds (n = 9), and bedsores (n = 5) were isolated and grew well on (nutrient agar, blood agar, and MacConkey gar) media. Ten patient’s specimens (20%) had no bacterial growth. The sensitivity of 40 bacterial isolates to 7 antibiotics was performed. A microscopic examination of 40 bacterial isolates by Gram-stained film was performed. Morphological and biochemical identifications of selected MDR bacteria were evaluated. The four MDR pathogenic bacteria are named S. aureus W, P. aeruginosa DF, K. pneumonia D, and K. pneumonia BS. Determination of MIC and MBC of the 3 strongest antibiotics against 4 multidrug resistant pathogenic bacteria. Antibacterial activities of six types of natural plant extracts were studied against tested pathogenic bacteria. Clove, garlic, and cinnamon boiling water extract showed inhibitory activity against MDR bacteria.